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SLICE

The New Standard for Accessible Light Sheet Imaging

BrightSLICE Software

BrightSLICE is a powerful, all-in-one software solution designed specifically for light-sheet microscopy. From acquisition to analysis, handle teravoxel-scale imaging with unprecedented ease and precision.

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Smart Acquisition

  • Real-time microscope control with intelligent parameter optimization

  • Multi-channel imaging with automated synchronization

  • Automated metadata logging for perfect experiment reproducibility

  • Save and load custom imaging protocols

Advanced Processing

    • Automated flatfield correction for uniform illumination

    • Seamless stitching of hundreds of image tiles

    • GPU-accelerated deconvolution (optional via NeuroDeblur®)

    • Sophisticated noise reduction and background correction

    • Flexible data compression without quality loss

High-Performance Visualization

  • Instant viewing of multi-terabyte datasets

  • GPU-accelerated 3D rendering

  • Real-time maximum intensity projections

  • Interactive sub-volume exploration

  • Professional-quality movie generation

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High-Performance Computing

  • Highly parallelized architecture

  • Advanced GPU optimization

  • Efficient memory management

  • Smart data streaming

  • Optimized memory management

  • Industry-standard file formats

  • Automated parameter logging

  • Comprehensive metadata tracking

Streamlined Workflow

    • Everything you need in one intuitive interface:

    • Seamless transition from acquisition to analysis

    • Batch processing capabilities

    • Automated quality control

    • Integrated data management

Research-Ready Output

  • Generate publication-quality data with comprehensive processing tools:

  • Multi-resolution data export in JPX and OME-TIFF formats

  • Publication-ready visualization

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Powerful Integration with the MBF Bioscience Ecosystem

  • Real-time microscope control with intelligent parameter optimization

  • Multi-channel imaging with automated synchronization

  • Automated metadata logging for perfect experiment reproducibility

  • Save and load custom imaging protocols

Third-Party Compatibility

    • Plays well with your existing tools through OME-TIFF export:

    • Fiji/ImageJ

    • Python

    • MATLAB

    • Napari

Technical Excellence

  • Parallel processing architecture

  • Advanced GPU acceleration

  • Advanced Image Data Compression

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Breakthrough Imaging. 
Unprecedented Value.

SLICE™: a paradigm shift in light-sheet microscopy that combines high performance with unprecedented affordability and a compact device footprint. Invented by leading researchers at Columbia University, SLICE delivers advanced 3D imaging capabilities to research labs of all sizes. This innovative system offers high-resolution imaging of biological samples, making it ideal for both individual laboratories and core facilities.

Key Benefits

  • Democratize Discovery: High-Performance Light Sheet Imaging Accessible to Every Lab

  • Exceptional Performance in a Compact, Benchtop Design

  • Compatibility with Diverse Clearing Techniques

  • Achieve High-Resolution Imaging Across Large Volumes of whole organs, organoids and biofilms

  • End-to-end Software Pipeline from Acquisition to Publication-Ready Data

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Why Choose SLICE?

​SLICE offers the power of advanced light-sheet microscopy at a fraction of the cost of conventional systems. Projected Light Sheet Microscopy (pLSM) is a cutting-edge imaging technique utilizing dynamic, modulated light sheets for high resolution visualization of cleared samples. This innovative approach enables multi-resolution imaging, compatibility with a variety of clearing methods and minimal photobleaching making it particularly valuable for fields like developmental biology, neuroscience, and other areas requiring detailed analysis of cleared intact specimens. SLICE embodies these advancements, delivering a compact design and user-friendly interface that makes cutting-edge imaging technology accessible to labs of all sizes.

 

SLICE delivers unmatched accessibility, giving every team member the freedom to explore, experiment, and uncover new possibilities—without barriers or boundaries. It’s designed to make the extraordinary within reach, offering the ultimate value without sacrificing innovation or quality.

 

Built on scientifically validated technology licensed from Columbia University's leading researchers, SLICE leverages cutting-edge methodology published in peer-reviewed literature (Chen et al 2024) and Highlighted in Nature Reviews Bioengineering.

 

SLICE is engineered so that it can also be placed in locations where experiments are actually happening – e.g. for higher biosafety labels, small lab spaces or even inside incubators.

Hardware Specifications

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Broad Sample Compatibility

The SLICE system is designed to work with a variety of sample preparation techniques:

  • Clearing Methods: Compatible with DISCO, CLARITY, SHANEL, CUBIC, BINAREE and other optical clearing techniques

  • Sample Mounting: Various size, quick-mount cuvettes support imaging of complexly shaped organs and tissues

  • Multi-Color Imaging: Compatible with commonly used fluorescent proteins and dyes

  • Sample Types: Whole mouse brains, human brain sections, organoids, bacterial biofilms

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Seamless Clarity: Real-time Automatic Refractive Index Correction

  • Achieve crystal-clear images even in challenging samples with SLICE's integrated refractive index correction. This advanced capability automatically compensates for optical distortions, ensuring uniform brightness and resolution throughout your cleared tissues.

  • Crucially, SLICE allows you to use any clearing technique and associated immersion media (e.g., iDISCO, CLARITY, SHANEL, CUBIC, BINAREE, and more without needing to make any physical changes to the system.

  • Unlike other light sheet microscopes that require manual adjustments or component swaps for each media type, SLICE adapts seamlessly, maximizing your flexibility and minimizing setup time.

Ready For Any Challange

SLICE has been rigorously tested on a wide range of samples:

    • Whole mouse brains

    • Human brain tissue samples

    • Brain and blood vessel organoids

    • Bacterial biofilms

Technical Support and Documentation

Our team provides comprehensive support to ensure optimal system performance:

    • Detailed user manual and technical documentation

    • Remote installation and setup assistance

    • Regular software updates and performance optimizations

    • Custom adaptation services for specific research needs

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