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MI-SIM

Machine Intelligent Structured Illumination Microscope

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Highlights

2D/3D Realtime Super Resolution

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First to realize real-time SR imaging, seeing is obtaining

Previewing at an 85 nm resolution, our system delivers a clear visualization of mitochondrial inner membrane structures, surpassing the resolution of standard preview methods. It boasts real-time reconstruction speeds of 24 Hz, with the capability to reach up to 65 Hz, facilitating the rapid acquisition of targeted samples for imaging. By bringing super-resolution (SR) imaging into the digital era, we significantly enhance imaging efficiency. This progress allows for quick evaluation of image quality and facilitates the prompt adjustment of regions of interest (ROI) and imaging protocols.

60nm

Super Resolution

Marking a pioneering advancement, our system is the first peer-reviewed technology to attain 60 nm resolution at the living cell level through a blend of optical and computational innovations. It facilitates detailed visualization of every marker and its distribution within living cells, enabling the observation of dynamic structures like the nuclear pore protein NUP98's ring structure, which also has a size of 60 nm.

Long-term
Live-cell Tracking

World's 1st to realize real-time intelligent tracking for long-term live cell imaging

Enhanced Tracking Precision: TRACKER revolutionizes long-term live cell imaging with its advanced ability to automatically adjust for 3D defocus and 2D shifts, ensuring clear focus and tracking accuracy despite cellular motion and morphological changes.

Comprehensive Multi-ROl Observation: Designed for detailed analysis, TRACKER adeptly monitors multiple regions of interest (ROIs), capturing crucial morphological and quantitative changes in cell growth, phagocytosis, and division for in-depth, long-term cellular studies.

Various Imaging Modes

Equipped with 25 imaging modes to match different samples

Large FOV Super Resolution

Large FOV super resolution under 100 × to overview all details

150 μm FOV with 100 × objective provides multi-cell overview. Enable the cross-scale overview observation of interactions. Meanwhile, keep the high imaging quality of full frame.

Data source: Huashan Zhao lab, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences

Low Photobleaching

Large FOV super resolution under 100 × to overview all details

150 μm FOV with 100 × objective provides multi-cell overview. Enable the cross-scale overview observation of interactions. Meanwhile, keep the high imaging quality of full frame.

Data source: Huashan Zhao lab, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences

High Throughput Multi-Site Imaging

Large FOV super resolution under 100 × to overview all details

150 μm FOV with 100 × objective provides multi-cell overview. Enable the cross-scale overview observation of interactions. Meanwhile, keep the high imaging quality of full frame.

Data source: Huashan Zhao lab, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences

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